Table 3.
Descriptive Information for LLFS Family Members and Controls
| Proband Generation | Offspring | |||||
|---|---|---|---|---|---|---|
| Controls (n = 138) | Probands Only (n = 348) | Proband Siblings (n =603) | Controls (n = 222) | Sons and Daughters (n =218) | Nieces and Nephews (n =341) | |
| Age | 83.84*** (5.96) | 93.58 (3.62) | 87.78 (5.87) | 70.51* (4.47) | 69.61 (3.90) | 70.92 (4.65) |
| Education | 10.40 (3.46) | 10.48 (3.92) | 10.01 (3.63) | 11.33** (3.73) | 12.35 (3.14) | 11.13 (3.88) |
| Female | 108*** (78%) | 144 (41%) | 328 (54%) | 77*** (35%) | 143 (66%) | 191 (56%) |
| Global Cognition | 27.29** (2.44) | 26.05 (3.13) | 25.56 (3.11) | 28.48* (1.95) | 28.89 (1.30) | 28.57 (1.60) |
| Immediate Memory | 8.06** (4.22) | 9.54 (4.34) | 8.50 (4.41) | 11.92** (4.32) | 13.02 (4.00) | 12.16 (3.92) |
| Delayed Memory | 5.74 (4.15) | 7.50** (4.43) | 6.36 (4.55) | 10.30 ** (4.80) | 11.48 (4.23) | 10.54 (4.46) |
| Digit Span Forward | 7.77 (2.16) | 7.72 (2.15) | 7.64 (2.13) | 7.91*** (2.13) | 8.74 (2.33) | 8.07 (2.12) |
| Digit Span Backward | 5.51 (2.07) | 5.54 (2.04) | 5.48 (2.02) | 6.07*** (1.92) | 6.93 (2.43) | 6.14 (2.18) |
| Animal Fluency | 15.81** (5.31) | 14.31 (5.11) | 14.83 (4.84) | 20.86 (5.96) | 20.48 (5.86) | 20.94 (5.38) |
| Vegetable Fluency | 12.14*** (4.42) | 9.92 (3.69) | 10.72 (4.07) | 13.61*** (4.20) | 15.06 (4.45) | 13.93 (4.16) |
| Digit Symbol | 34.70*** (12.28) | 27.27 (11.75) | 29.94 (12.06) | 41.18*** (11.78) | 46.99 (11.73) | 42.18 (11.36) |
Note. Group differences were examined across probands versus controls, and sons/daughters versus controls.
*
p< .05,
**
p < .01,
***
p < .001.