Table 4.

Likelihood of cognitive impairment in long lived individuals and their relatives versus spouse controls, adjusted for age, education and study site.

	No. at Risk	Affected N (%)	Mean Age of Cases	Age, Education and Study Site Adjusted Odds Ratio
65–79 years
Sons and Daughters	213	11(5.5)	69.9 ± 3.7	0.4 (0.2–0.9)
Nieces and Nephews in the Offspring Generation	328	37 (11.3)	71.3 ± 4.7	0.8 (0.4–1.4)
Spouse Controls	216	28 (13.0)	71.7 ± 4.5	1.0 (reference)
80–95 years
Probands	232	121 (52.2)	92.3 ± 2.3	0.7 (0.4–1.4)
Siblings in the Proband Generation	485	259 (53.4)	89.2 ± 2.9	1.1 (0.7–1.7)
Spouse Controls	103	45 (43.7)	86.9 ±3.8	1.0 (reference)