Fig. 3.
Estradiol accelerated lung metastasis progression in mice receiving 5 × 103 4T1 cells via the lateral TV. a Estradiol decreased the half time for bioluminescent signals emitted from metastatic tumors on the lungs to reach saturation (P < 0.05). Half time for bioluminescent signals to reach saturation (ST1/2) was recorded for each mouse. When bioluminescent signal from an individual mouse did not reach saturation by the end of the study, ST1/2 for this mouse was set as 21 (the duration of the study). Mice without detected bioluminescent signals were excluded. Triangle: individual ST1/2, dash median ST1/2 for experimental groups, b Top panel a series of bioluminescent images of a mouse from the control group (CTL) recorded on D7, D11, D14, D18 and D21. Bottom panel a series of bioluminescent images of a mouse from the estradiol group (E2) recorded on D7, Dll, D14, D18 and D21. Bioluminescent signals from the estradiol mouse reached saturation faster than from the control mouse