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. 2014 Aug 22;7:52. doi: 10.1186/1755-8794-7-52

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Copyright © 2014 Lee et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Interaction network among 24 seed nodes (marked as black circle) and their 80 interacted nodes (marked as grey circle) using three Cytoscape plug-ins. Six seed nodes (KLKB1, KARS, NRXN2, LAMA3, PRNP, and APOE) clustered according to the KEGG pathway criteria were annotated by red squares and indicated by red arrows. The six interaction nodes with seed node were annotated by black squares and indicated by black arrows. The apoptosis cluster (path: hsa04210) was expanded using GO data [apoptosis (GO: 0006915), anti-apoptosis (GO: 0006916), induction of apoptosis (GO: 0006917), induction of apoptosis by intracellular signals (GO: 0008629), regulation of apoptosis (GO: 0042981), and positive regulation of apoptosis (GO: 0043065)].