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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Bioessays. 2014 Jun 5;36(8):778–787. doi: 10.1002/bies.201400017

Figure 2.

Figure 2

Principal melatonin-receptor signaling pathways. Depending on the type of melatonin-receptor complexes present in cells (MT1 homomers, MT2 homomers, or MT1/MT2 heteromers), the depicted signaling pathways are activated upon melatonin stimulation. Thickness of the arrows represents the potency and efficiency of the activation of the pathway. DAG, diacylglycerol; ERK, extracellular signal-regulated kinase; IP3, inositol triphosphate; MUPP1, multi-PDZ domain protein 1; pCREB, phospho-cAMP-response element-binding protein; PLC, phospholipase C; PKA, protein kinase A; PKC, protein kinase C; RGS20, regulator of G protein signaling 20; sGC, soluble guanylyl cyclase.