Table 2.
Event Rates in Patients With HF With Systolic Dysfunction With and Without Anemia at Baseline and Discharge
| Outcome | Baseline Anemia Status
|
P Value | By Discharge Anemia Status in Patients Anemic at Baseline |
P Value | By Discharge Anemia Status in Entire Cohort |
P Value | |||
|---|---|---|---|---|---|---|---|---|---|
| Anemia (n=1277) |
No Anemia (n=2454) |
Persistent Anemia (n=851) |
Resolved Anemia (n=308) |
Anemia (n=979) | No Anemia (n=2474) |
||||
| All-cause mortality | 431 (33.8) | 542 (22.1) | <0.001 | 307 (36.1) | 71 (23.1) | <0.001 | 380 (35.3) | 556 (20.8) | <0.001 |
| CV mortality or HF hospitalization | 649 (50.8) | 871 (35.5) | <0.001 | 464 (54.5) | 118 (38.3) | <0.001 | 584 (54.2) | 936 (35.1) | <0.001 |
| CV mortality | 321 (25.1) | 424 (17.3) | <0.001 | 225 (26.4) | 55 (17.9) | 0.003 | 283 (26.3) | 444 (16.6) | <0.001 |
| HF | 195 (15.3) | 208 (8.5) | <0.001 | 136 (16) | 26 (8.4) | 0.001 | 165 (15.3) | 206 (7.7) | <0.001 |
| Sudden cardiac death | 91 (7.1) | 156 (6.4) | 0.37 | 63 (7.4) | 23 (7.5) | 0.97 | 83 (7.7) | 178 (6.7) | 0.26 |
| Stroke | 8 (0.6) | 15 (0.6) | 0.96 | 4 (0.5) | 3 (1.0) | 0.39 | 5 (0.5) | 15 (0.6) | 0.81 |
| Acute MI | 8 (0.6) | 16 (0.7) | 0.93 | 7 (0.8) | 1 (0.3) | 0.69 | 9 (0.8) | 17 (0.6) | 0.51 |
| Other CV mortality | 19 (1.5) | 29 (1.2) | 0.43 | 15 (1.8) | 2 (0.6) | 0.37 | 21 (1.9) | 28 (1.0) | 0.028 |
| Non-CV mortality* | 71 (5.6) | 63 (2.6) | <0.001 | 59 (6.9) | 7 (2.3) | 0.002 | 68 (6.3) | 60 (2.2) | <0.001 |
| Clinically worsening HF | 597 (46.8) | 747 (30.4) | <0.001 | 439 (51.6) | 96 (31.2) | <0.001 | 544 (50.5) | 790 (29.6) | <0.001 |
| CV hospitalization | 740 (57.9) | 1021 (41.6) | <0.001 | 437 (51.4) | 122 (39.6) | <0.001 | 547 (50.8) | 923 (34.6) | <0.001 |
| HF hospitalization | 450 (35.2) | 579 (23.6) | <0.001 | 337 (39.6) | 82 (26.6) | <0.001 | 421 (39.1) | 634 (23.8) | <0.001 |
| MI hospitalization | 19 (1.5) | 20 (0.8) | 0.06 | 13 (1.5) | 4 (1.3) | 1.00 | 17 (1.6) | 22 (0.8) | 0.040 |
| Stroke hospitalization | 15 (1.2) | 31 (1.3) | 0.82 | 12 (1.4) | 2 (0.6) | 0.38 | 13 (1.2) | 33 (1.2) | 0.94 |
| Arrhythmia hospitalization | 45 (3.5) | 69 (2.8) | 0.23 | 21 (2.5) | 19 (6.2) | 0.002 | 31 (2.9) | 84 (3.1) | 0.67 |
| Other CV hospitalization | 76 (6) | 134 (5.5) | 0.54 | 54 (6.3) | 15 (4.9) | 0.35 | 65 (6.0) | 150 (5.6) | 0.62 |
Expressed as events (%). CV indicates cardiovascular; HF, heart failure; and MI, myocardial infarction.
*
CV plus non-CV mortality does not add up to total mortality because there were deaths that were not successfully adjudicated.