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. 2014 Sep 2;8:671. doi: 10.3389/fnhum.2014.00671

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Copyright © 2014 Ganzetti, Wenderoth and Mantini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of bias correction on T1-w and T2-w images. A modality-dependent bias correction procedure was performed for both T1-w and T2-w. To illustrate the relative results, we analyzed the T1-w (A,C,E) and T2-w histogram (B,D,F) of three representative subjects from the IXI 1.5 T (Subject 002), IXI 3 T (Subject 093) and KIRBY21 (Subject 30) databases, respectively. Specifically, we compared the histograms before (blue line) and after bias-correction (red line). Before correction, the T1-w image of IXI 1.5 T dataset (A) was less biased than the IXI 3 T (C) and the KIRBY21 3 T (E), with an average correlation of r = 0.73. After bias correction, this correlation increased to r = 0.89. Conversely, in the T2-w image minor changes were observed, with an average correlation between histograms being r = 0.96 and r = 0.97 before and after bias correction, respectively.