Table 5.

Unadjusted and adjusted odds of extreme obesity (BMI of 40 or higher), an underlying operative diagnosis of RA/inflammatory arthritis, Deyo-Charlson index of 3 or higher, depression or anxiety over time

	1993–1995	1996–1998	1999–2001	2002–2005
BMI ≥40 (extreme obesity)
Unadjusted	Ref	1.62 (1.20, 2.18)†	2.13 (1.59, 2.84)*	2.37 (1.81, 3.10)*
Age- and sex-adjusted	Ref	1.50 (1.11, 2.03)†	1.98 (1.48, 2.67)*	2.19 (1.67, 2.88)*
Comorbidity-adjusted	Ref	1.62 (1.20, 2.18)†	2.12 (1.58, 2.82)*	2.34 (1.78, 3.06)*
Age-, sex- and comorbidity adjusted	Ref	1.51 (1.11, 2.05)†	1.96 (1.46, 2.63)*	2.11 (1.60, 2.78)*
Diagnosis of RA/ inflammatory arthritis
Unadjusted	Ref	0.79 (0.58, 1.07)	0.50 (0.35, 0.70)*	0.21 (0.15, 0.31)*
Age- and sex-adjusted	Ref	0.72 (0.53, 0.97)¶	0.44 (0.31, 0.63)*	0.19 (0.13, 0.27)*
Comorbidity-adjusted	Ref	0.79 (0.58, 1.07)	0.48 (0.34, 0.68)*	0.20 (0.14, 0.29)*
Age-, sex- and comorbidity adjusted	Ref	0.72 (0.53, 0.97)¶	0.43 (0.30, 0.61)*	0.17 (0.11, 0.24)*
Deyo-Charlson Index ≥3
Unadjusted	Ref	1.11 (0.90, 1.34)	1.57 (1.39, 1.92)*	2.11 (1.76, 2.53)*
Age- and sex-adjusted	Ref	1.17 (0.94, 1.45)	1.66 (1.35, 2.04)*	2.26 (1.88, 2.72)*
Depression
Unadjusted	Ref	1.77 (1.29, 2.43)*	2.61 (1.93, 3.53)*	4.04 (3.06, 5.34)*
Age- and sex-adjusted	Ref	1.76 (1.28, 2.42)*	2.61 (1.92, 3.53)*	4.06 (3.07, 5.36)*
Comorbidity-adjusted	Ref	1.79 (1.30, 2.46)*	2.56 (1.89, 3.47)*	3.84 (2.90, 5.07)*
Age-, sex- and comorbidity adjusted	Ref	1.77 (1.29, 2.44)*	2.54 (1.87, 3.44)*	3.81 (2.88, 5.03)*
Anxiety
Unadjusted	Ref	1.30 (0.93, 1.82)	1.33 (0.95, 1.86)	2.27 (1.70, 3.04)*
Age- and sex-adjusted	Ref	1.32 (0.94, 1.85)	1.35 (0.97, 1.89)	2.33 (1.74, 3.11)*
Comorbidity-adjusted	Ref	1.32 (0.94, 1.84)	1.30 (0.93, 1.82)	2.13 (1.60, 2.85)*
Age-, sex- and comorbidity adjusted	Ref	1.32 (0.94, 1.85)	1.30 (0.93, 1.83)	2.16 (1.61, 2.89)*

Ref, reference category

Osteoarthritis is the reference for diagnosis

^¶P<0.05;

^†P<0.01;

^*P<0.001