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LRH-1 and SF-1 Binding and Activation of Alkoxy-Substituted Series 12
 | |||
|---|---|---|---|
| compound | R | pEC50 (RE) |
|
| LRH-1 | SF-1 | ||
| 5 | 6.2 (0.89) | 6.8 (0.36) | |
| 7 | 7.5 (0.38) | 7.4 (0.70) | |
| 12a | Me | ia | ia |
| 12b | Et | 5.6 (0.17) | 6.3 (0.55) |
| 12c | nPr | 5.6 (0.21) | 6.7 (0.67) |
| 12d | iPr | 5.5 (0.19) | 6.4 (0.49) |
| 12e | nBu | 5.3 (0.39) | 6.6 (0.62) |
| 12f | CH2CH(Me)(Et) | 5.6 (0.18) | 6.7 (0.56) |
| 12g | nPent | ia | 6.4 (0.43) |
| 12h | nHex | ia | ia |
| 12i | cHex | 6.1 (0.16) | 7.1 (0.66) |
| 12j | CH2Ph | 7.0 (0.13) | ia |
