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Variation of Bridgehead Substituent in Series 18 Compounds
 | |||
|---|---|---|---|
| compound | R | pEC50 (RE) |
|
| LRH-1 | SF-1 | ||
| 18a | Ph | 6.6 (0.24) | 7.2 (0.78) |
| 18b | 3-MeOPh | 6.5 (0.25) | 7.2 (0.28) |
| 18c | 4-MeOPh | ia | ia |
| 18d | 4-MePh | 5.7 (0.25) | 6.8 (0.28) |
| 18e | 4-EtPh | ia | ia |
| 18f | 4-nBuPh | 6.0 (0.14) | ia |
| 18g | 4-tBuPh | ia | ia |
| 18h | 4-PhPh | ia | ia |
| 18i | nPr | 5.5 (0.23) | 6.8 (0.66) |
| 18j (RJW102) | nBu | 5.6 (0.19) | 6.7 (0.76) |
| 18k | nHex | ia | ia |
| 18l | nOct | ia | ia |
