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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: J Med Chem. 2011 Mar 10;54(7):2266–2281. doi: 10.1021/jm1014296

Table 6.

Variation of 2-Substituent in Series 18 Compounds

graphic file with name nihms618140t4.jpg
compound R pEC50 (RE)
LRH-1 SF-1
18a Ph 6.6 (0.24) 7.2 (0.78)
18m 3-MeOPh 6.6 (0.13) 6.9 (0.42)
18n 4-EtPh ia ia
18o nPr ia 6.4 (0.56)
18p nBu ia 6.6 (0.59)
18q nHex ia ia
18r cHex 5.9 (0.15) 6.7 (0.59)
18s (RJW101) (CH2)3OH 6.1 (0.38) ia