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Effect of Oxygen Substitution on the Cyclopentane Ring
 | ||
|---|---|---|
| compound | pEC50 (RE) |
|
| LRH-1 | SF-1 | |
| 18a | 6.6 (0.24) | 7.2 (0.78) |
| 24-exo (RJW100) | 6.6 (1.00) | 7.5 (1.00) |
| 24-endo | 6.4 (0.67) | 7.2 (0.77) |
| 25-exo | 6.4 (0.18) | 6.4 (0.25) |
| 25-endo | 6.6 (0.18) | 7.1 (0.24) |
| 29-exo | 6.0 (0.53) | 6.6 (0.49) |
| 29-endo | 5.8 (0.33) | 6.5 (0.95) |
| 30-exo | ia | ia |
| 30-endo | 6.3 (0.13) | 6.7 (0.34) |
