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. 2014 Aug 19;2014:743450. doi: 10.1155/2014/743450

Table 1.

Validated targets for deregulated miRNAs in ATC.

miRNAs Validated targets Cellular processes References
Downregulated miRs miR-200 family ZEB1 ZEB2 β-Catenin EMT and proliferation [21, 67]
miR-30 family Beclin1 EZH2 VIM Autophagy, chromatin condensation, and EMT [30, 33, 67]
let-7 family RAS HMGA2 LIN28 Proliferation, histone modification, and stemness [67, 68]
miR-25 EZH2 BIM KLF4 Chromatin condensation and apoptosis [30, 67]
miR-125 MMP1 HMGA2 LIN28A Invasion, histone modification, and stemness [20, 67, 69]

Upregulated miRs miR-221/miR-222 p27 RECK PTEN Cell cycle, growth, and invasion [20, 67]
miR-17-92 cluster p21 TIMP3 PTEN Cell growth and invasion [45, 67]
miR-146a/miR-146b NFκB THRB SMAD4 Cell differentiation, proliferation, and invasion [52, 67, 70, 71]