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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Stem Cells. 2014 Apr;32(4):860–873. doi: 10.1002/stem.1584

Figure 3. Lin28a mutant mice show reduced testis weight and sperm number.

Figure 3

(A and B) Body and testis weights were measured in control and Lin28a mutant males at 8 and 20 weeks of age. In comparison to control, Lin28a mutant males exhibited no body weight difference at 8 or 20 weeks of age, yet showed significant reductions in testis weight and sperm number at these time points. (C) Lin28a mutant epididymal sperm counts revealed significant reductions in sperm number by 8 and 20 weeks of age. (n=5). (D) Fertility testing showed that 5–6 month old mutant Lin28a males were able to sire litters of comparable sizes to controls when mated with 12-week old fertile FVB/N females. (n=3). Values represent the mean ± SEM. * Indicates P≤0.01. (E) PAS-stained histological cross-sections of 20-week-old Lin28a control and mutant testes showed no severe abnormalities. Scale bar = 20 um.