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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: J Med Chem. 2011 Mar 10;54(7):2391–2398. doi: 10.1021/jm101532u

Chart 2.

Chart 2

Topo-IIα Inhibition Activity (IC50) and Antiproliferative Activity (GI50) of the TSCs and CuII(TSC)Cl Complexesb

aThe Topo-IIα inhibition IC50 for etoposide, merbarone, and doxorubicin vary somewhat in the literature; in this chart, a range of concentrations and representative publications are presented. bTopo-IIα inhibition IC50 values were determined via the described agarose gel supercoiled DNA relaxation assay employing a range of drug concentrations from 500 μM to 10 nM. Cell proliferation GI50 values were determined via MTT assay with drug concentrations ranging from 500 μM to 10 nM. All experiments were performed in triplicate, and all values are shown with (1 SD.