Table 3.
Meta-analysis of the association between COX-2 polymorphisms and breast cancer risk.
| Comparisons | OR | 95% CI | P value | Heterogeneity | Effects model | |
|---|---|---|---|---|---|---|
| I 2 | P value | |||||
| B versus A | ||||||
| rs20417 | 1.04 | 0.98–1.10 | 0.17 | 56% | 0.06 | R |
| Caucasian | 1.02 | 0.96–1.08 | 0.50 | 0% | 0.92 | F |
| Asian | 1.45 | 1.15–1.84 | 0.002 | 0% | 0.47 | F |
| rs689466 | 0.99 | 0.94–1.04 | 0.69 | 33% | 0.21 | F |
| Caucasian | 0.97 | 0.92–1.03 | 0.34 | 0% | 0.58 | F |
| Asian | 1.14 | 0.97–1.33 | — | — | — | — |
| rs5275 | 1.01 | 0.98–1.05 | 0.50 | 56% | 0.01 | R |
| Caucasian | 1.00 | 0.97–1.04 | 0.80 | 41% | 0.09 | R |
| Asian | 1.03 | 0.89–1.19 | 0.70 | 0% | 0.51 | F |
| BB versus AA | ||||||
| rs20417 | 1.21 | 1.02–1.42 | 0.03 | 0% | 0.97 | F |
| Caucasian | 1.20 | 1.02–1.42 | 0.03 | 0% | 0.92 | F |
| Asian | 1.54 | 0.49–4.78 | 0.46 | 0% | 0.68 | F |
| rs689466 | 1.01 | 0.88–1.15 | 0.93 | 22% | 0.28 | F |
| Caucasian | 0.95 | 0.82–1.10 | 0.52 | 0% | 0.69 | F |
| Asian | 1.31 | 0.95–1.80 | — | — | — | — |
| rs5275 | 1.04 | 0.96–1.12 | 0.34 | 66% | 0.0008 | R |
| Caucasian | 1.01 | 0.94–1.10 | 0.72 | 58% | 0.01 | R |
| Asian | 1.26 | 0.85–1.85 | 0.25 | 7% | 0.30 | F |
| AB versus AA | ||||||
| rs20417 | 0.97 | 0.91–1.03 | 0.35 | 93% | <0.00001 | R |
| Caucasian | 0.94 | 0.88–1.01 | 0.07 | 95% | <0.00001 | R |
| Asian | 1.49 | 1.15–1.91 | 0.002 | 0% | 0.53 | F |
| rs689466 | 0.98 | 0.92–1.05 | 0.59 | 0% | 0.59 | F |
| Caucasian | 0.97 | 0.91–1.04 | 0.44 | 0% | 0.74 | F |
| Asian | 1.16 | 0.87–1.54 | — | — | — | — |
| rs5275 | 0.99 | 0.95–1.04 | 0.81 | 0% | 0.56 | F |
| Caucasian | 0.99 | 0.95–1.04 | 0.81 | 0% | 0.47 | F |
| Asian | 0.96 | 0.80–1.14 | 0.96 | 0% | 0.78 | F |
| AB + BB versus AA | ||||||
| rs20417 | 1.01 | 0.96–1.08 | 0.64 | 54% | 0.05 | R |
| Caucasian | 1.00 | 0.93–1.06 | 0.93 | 0% | 0.84 | F |
| Asian | 1.49 | 1.16–1.91 | 0.002 | 0% | 0.49 | F |
| rs689466 | 0.90 | 0.87–0.95 | 0.0005 | 94% | <0.00001 | R |
| Caucasian | 0.88 | 0.83–0.94 | <0.0001 | 96% | <0.00001 | R |
| Asian | 1.21 | 0.92–1.58 | — | — | — | — |
| rs5275 | 1.02 | 0.98–1.07 | 0.33 | 62% | 0.002 | R |
| Caucasian | 1.02 | 0.97–1.07 | 0.42 | 66% | 0.002 | R |
| Asian | 0.99 | 0.84–1.17 | 0.92 | 0% | 0.86 | F |
| BB versus AA + AB | ||||||
| rs20417 | 1.22 | 1.03–1.43 | 0.02 | 0% | 0.98 | F |
| Caucasian | 1.21 | 1.03–1.43 | 0.02 | 0% | 0.94 | F |
| Asian | 146 | 0.47–4.56 | 0.51 | 0% | 0.70 | F |
| rs689466 | 1.01 | 0.89–1.15 | 0.85 | 0% | 0.48 | F |
| Caucasian | 0.96 | 0.83–1.11 | 0.59 | 0% | 0.76 | F |
| Asian | 1.18 | 0.92–1.51 | — | — | — | — |
| rs5275 | 1.04 | 0.97–1.12 | 0.27 | 65% | 0.0009 | R |
| Caucasian | 1.02 | 0.95–1.10 | 0.60 | 60% | 0.01 | R |
| Asian | 1.28 | 0.87–1.87 | 0.21 | 15% | 0.28 | F |
A: represents the major allele; B: represents the minor allele; F: fixed-effects model; R: random-effects model.