Figure 1.
TRF-mediated telomeric D-loop formation. (A) Diagram of the D-loop assay. (B) TRF2 and TRF2ΔB promote telomeric D-loop formation with an activity peak when included at a final protein concentration between 100 nM (lane 3) and 150 nM (lane 4). (C) TRF2ΔM and TRF1 promote telomeric D-loop formation only at higher concentrations.