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Effects of inhibitor compounds on the efficiency of MYC-induced oncogenic transformation
| Compound (10 µM) | EOT* |
| KJ-Pyr-4 | 1.12 |
| KJ-Pyr-6 | 0.79 |
| KJ-Pyr-9 | 0.00083 |
| KJ-Pyr-10 | 0.00017 |
Efficiency of transformation indicates focus counts in the presence of inhibitor over focus counts of control plates. Oncogenic transformation was determined in chicken embryo fibroblasts using the RCAS vector expressing ATG-MYC in which the noncanonical initiation codon CTG had been optimized to ATG.
