Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 11;111(34):12538–12543. doi: 10.1073/pnas.1408805111

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 1. — Pirenzepine (Pire) blocks the nicotine-induced increase in NMDAR/AMPAR ratios. (A) Traces show examples of NMDAR/AMPAR ratios obtained from animals treated with the indicated substance. Total EPSCs comprising both AMPAR- and NMDAR-mediated EPSCs were first recorded (a), and 2-amino-5-phosphopentanoate (40 μM) was then applied to obtain the AMPA EPSC (b). (c) NMDA EPSC was obtained by digital subtraction of the AMPA EPSC from the initial EPSC. (B) Summary of NMDAR/AMPAR ratios obtained from animals administered PBS, Pire, nicotine (Nic), or Pire + Nic. ***P < 0.001.