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. 2014 Aug 11;111(34):12538–12543. doi: 10.1073/pnas.1408805111

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Fig. 5. — Repeated nicotine, donepezil, and RS86 treatment enhances the NR2B component of NMDAR-mediated EPSCs. (A–D) NMDAR-mediated EPSCs were recorded in the presence of 6,7-dinitroquinoxalline-2,3-dione to block AMPAR-mediated EPSCs. To assess the effects of nicotine, donepezil, and RS86 exposure on the NR2B component of NMDAR-mediated EPSCs, the Ifen sensitivity of NMDAR EPSCs was monitored. The time course of the effect of Ifen on the amplitude of NMDAR EPSCs is shown as percentage changes (mean ± SEM) in the peak amplitude of the responses. Representative traces above the graph were taken before and 25 min after bath application of Ifen (3 μM). Effects of bath application of Ifen on NMDAR EPSCs in naive (A), nicotine-exposed (B), donepezil-exposed (C), and RS86-exposed (D) rats are shown. (E) Summary of the ifenprodil-sensitive component of NMDAR-mediated EPSCs obtained from naive, Nic-, Done-, and RS86-treated rats. *P < 0.05.