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. 2014 Aug 13;111(34):E3544–E3552. doi: 10.1073/pnas.1413201111

Fig. 5.

Fig. 5.

Calcineurin substrates in α-syn transgenic mice. (A) Western blot for phosphoserine 657, PKCα from brain lysates of 12-mo-old α-syn transgenic mice. PKCα serves as loading control. (B) Immunohistochemistry for NFATc4 in neurons from the mitral cell layer in the olfactory bulb of 13-mo-old α-syn transgenic mice and control (C) mice (Upper). Immunohistochemistry for NFATc3 in glia from the internal plexiform layer in the olfactory bulb of 13-mo-old α-syn transgenic. Immunohistochemistry for glial fibrillary acid protein (GFAP) for normal and reactive astrocytes in the internal plexiform layer of the olfactory bulb. Similarly, immunostaining for Iba-1 from normal and activated microglia in the nodules of the internal plexiform layer of the olfactory bulb of α-syn transgenic mice. Error bars reflect variability between two sections analyzed from a total of five animals in each group. *P < 0.05 (Student t test).