Figure 1.

Sensitivity of the H3122 cell line to ALK inhibitors (crizotinib and alectinib). To examine the sensitivity of ALK inhibitors, we used an MTT assay. The experiment was performed in triplicate. (A) Growth inhibitory effect of crizotinib. The H3122 cell line was sensitive to crizotinib under a normoxic state, compared with a hypoxic state. The graphs, mean of independent triplicate experiments; error bars, SD. (B) IC₅₀ of ALK inhibitors. The IC₅₀ values of both inhibitors in the H3122 cell lines were significantly higher under hypoxia than under normoxia (crizotinib, ^*P=0.028 and alectinib, ^*P=0.0035). ^*P<0.05.