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IGF-I controls the expression of MDR1 and P-gp in leukemic cells. The cell lines were incubated in the presence of IGF-I or PPP for 12 h. The expression of MDR1 was analyzed by RT-PCR (A). The expression of P-gp protein was studied by flow cytometry using anti-CD243-PE. Isotypic IgG2a was used as negative control (B).
