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Auranofin downregulates IKK-β expression and promotes the nuclear translocation of FOXO3 protein in SKOV3 cells. SKOV3 cells were treated with auranofin (25, 50 and 100 nM) or control (0 nM) for 48 h and cytoplasmic and nuclear extracts that had been fractionated from cells were analyzed by western blot analysis with specific antibodies as indicated. β-actin and PARP1 represent the loading controls of cytoplasmic and nuclear extracts, respectively.
