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Characteristics of the established pancreatic cancer cell lines.
| CSC-properties | CSClow BxPc-3 |
CSChigh MIA-PaCa2 |
Refs. |
|---|---|---|---|
| Source | Primary tumor | Primary tumor | ATCC |
| Tumor grade | G2 | G3 | (31) |
| p53 status | MT | MT | (31) |
| K-ras status | WT | MT | (31) |
| In vitro morphology | Densely attached | Loosely attached | (15) |
| Self renewal capacity | |||
| Colony-formation | + | +++ | (14,32) |
| Spheroid formation | − | +++ | (14,32) |
| ALDH1 activity | + | +++ | (14,32) |
| Gemcitabine resistance | + | +++ | (14) |
| E-cadherin | +++ | − | (18) |
| Vimentin | + | +++ | (18) |
