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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jun 14;1846(1):188–200. doi: 10.1016/j.bbcan.2014.06.001

Table 2.

Rodent models of WWOX ablation

Model Target Tissue Observed phenotypes Tumors Reference
Wwoxgt/gt hypomorph mouse All tissues

  • Moderately Shorter lifespan

  • Reduced fertility

  • Testicular atrophy

 B-cell lymphomas in older female mice 49
Wwox −/− mouse All tissues

  • Viability 2–3 wks

  • Sever Dwarfism

  • Hypoglycemia

  • Delayed bone formation/osteopenia

  • Increased osteoclast activity

  • Gonadal abnormalities

  • Altered steroidogenesis

 Lesions compatible with periosteal osteosarcomas in 4 of 13 KO mice 50,52
EIIA-Cre;Wwoxfl/fl mouse All tissues

  • Viability 3 wks

  • Severe Dwarfism

  • Hypocapnia

  • Leukopenia

  • Hypoglycemia

  • Splenic atrophy

  • Delayed bone formation/osteopenia

  • Epileptic seizures

  • Ataxia

 No 51
Ide/Ide rat, spontaneous Wwox mutation All tissues

  • Viability 3–12 wks

  • Severe Dwarfism

  • Audiogenic epileptic seizures

  • Low plasma levels of LH and FSH

  • Leydig cells dysfunction

 No 103
BK5-Cre;Wwoxfl/fl mouse Skin, mammary gland and other Keratin5 expressing epithelia

  • Viability 10–17 wks

  • Impaired mammary branching

 No 55
MMTV-Cre; Wwoxfl/fl mouse Mammary & salivary glands

  • Normal lifespan

  • Impaired mammary branching

 No 55
Alb-Cre; Wwoxfl/fl mouse Liver

  • Normal lifespan

  • Altered lipid metabolism

 No 58
Osx-Cre; Wwoxfl/fl mouse Bone (osteoblasts)

  • Normal lifespan

  • No bone defects

 No Aldaz Lab, unpublished