Table 3.

Standardized mortality ratios in population-based cohort of 5-year survivors of ductal carcinoma in situ of the breast*

Cause	ICD-10	Observed	SMR (95% CI)	AER
All causes†	A00-Y89	941	1.04 (0.97 to 1.11)	5.7
Unknown cause		6
Circulatory system	I00-99	195	0.77 (0.67 to 0.89)	−10.2
Myocardial infarction	I21-22	43	0.83 (0.60 to 1.11)	−1.6
Other ischemic heart disease	I20, 23-25	15	0.78 (0.44 to 1.29)	−0.7
Other heart disease	I30-33, 39-52	47	0.69 (0.50 to 0.91)	−3.8
Cerebrovascular disease	I60-69	52	0.77 (0.58 to 1.01)	−2.7
Other cardiovascular disease	I00-15, 26-28, 34-52, 70-99	38	0.83 (0.59 to 1.14)	−1.4

* Time at risk started 5 years after ductal carcinoma in situ diagnosis. Patients were censored at diagnosis of a second neoplasia treated with chemotherapy or radiotherapy above the diaphragm or date of emigration. AER = absolute excess risk per 10,000 patients per year; CI = confidence interval; ICD-10 = International Classification of Diseases, 10th Revision; SMR = standardized mortality ratio.

† Without taking censoring for second neoplasia into account.