Table 4.
Risks of different cardiovascular diseases in 5-year survivors of ductal carcinoma in situ by age, follow-up interval, treatment, and laterality*
| Patient characteristics | Circulatory system† | Myocardial infarction‡ | Other ischemic heart disease§ | Other heart disease|| | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| O | SMR (95% CI) | AER | O | SMR (95% CI) | AER | O | SMR (95% CI) | AER | O | SMR (95% CI) | AER | |
| Age at DCIS diagnosis, y | ||||||||||||
| <49 | 0 | 0.0 (0.00 to 0.56) | −5.0 | 0 | 0.0 (0.00 to 2.19) | −1.3 | 0 | 0.0 (0.00 to 10.12) | −0.3 | 0 | 0.0 (0.00 to 2.30) | −1.2 |
| 50–59 | 23 | 0.6 (0.38 to 0.91) | −6.5 | 8 | 0.9 (0.37 to 1.69) | −0.6 | 2 | 0.7 (0.08 to 2.44) | −0.4 | 6 | 0.7 (0.24 to 1.41) | −1.4 |
| 60–69 | 97 | 0.7 (0.58 to 0.87) | −23.0 | 17 | 0.6 (0.35 to 0.97) | −6.5 | 6 | 0.6 (0.21 to 1.24) | −2.7 | 22 | 0.6 (0.38 to 0.92) | −8.3 |
| 70–74 | 75 | 1.0 (0.82 to 1.30) | 7.3 | 18 | 1.4 (0.83 to 2.20) | 13.8 | 7 | 1.3 (0.54 to 2.75) | 4.8 | 23 | 0.9 (0.55 to 1.31) | −8.2 |
| Treatment period DCIS | ||||||||||||
| 1989–1992 | 66 | 0.7 (0.56 to 0.91) | −17.4 | 13 | 0.7 (0.37 to 1.17) | −4.0 | 5 | 0.7 (0.24 to 1.69) | −1.3 | 32 | 0.9 (0.58 to 1.20) | −3.7 |
| 1993–1996 | 69 | 0.8 (0.63 to 1.03) | −7.9 | 16 | 0.9 (0.52 to 1.48) | −0.8 | 5 | 0.8 (0.25 to 1.82) | −0.7 | 26 | 0.7 (0.45 to 1.01) | −5.7 |
| 1997–2000 | 36 | 0.8 (0.56 to 1.10) | −7.5 | 8 | 0.9 (0.38 to 1.72) | −0.9 | 4 | 1.2 (0.32 to 2.99) | 0.5 | 20 | 0.9 (0.52 to 1.32) | −2.5 |
| 2001–2004 | 24 | 0.8 (0.49 to 1.14) | −7.5 | 6 | 0.9 (0.34 to 2.03) | −0.5 | 1 | 0.4 (0.01 to 2.33) | −1.4 | 14 | 0.9 (0.53 to 1.55) | −0.9 |
| Follow-up interval, y | ||||||||||||
| 5–9 | 96 | 0.8 (0.63 to 0.96) | −7.4 | 28 | 1.0 (0.67 to 1.46) | 0.1 | 7 | 0.7 (0.30 to 1.51) | −0.7 | 23 | 0.8 (0.48 to 1.13) | −2.1 |
| 10–15 | 75 | 0.8 (0.66 to 1.04) | −9.1 | 14 | 0.8 (0.44 to 1.34) | −2.1 | 4 | 0.6 (0.16 to 1.52) | −1.6 | 16 | 0.6 (0.36 to 1.03) | −5.6 |
| >15 | 24 | 0.6 (0.39 to 0.90) | −37.3 | 1 | 0.1 (0.00 to 0.83) | −13.8 | 4 | 1.4 (0.39 to 3.66) | 2.9 | 8 | 0.6 (0.28 to 1.27) | −10.6 |
| DCIS treatment | ||||||||||||
| Surgery only | 159 | 0.8 (0.65 to 0.89) | −10.8 | 35 | 0.8 (0.57 to 1.14) | −1.2 | 13 | 0.8 (0.44 to 1.42) | −0.6 | 82 | 0.8 (0.66 to 1.02) | −3.7 |
| Radiotherapy | 36 | 0.8 (0.55 to 1.10) | −8.0 | 8 | 0.8 (0.37 to 1.67) | −0.6 | 2 | 0.6 (0.07 to 2.09) | −1.2 | 11 | 0.7 (0.36 to 1.29) | −3.5 |
| Right-sided radiotherapy | 19 | 0.9 (0.55 to 1.43) | −3.4 | 2 | 0.5 (0.06 to 1.67) | −4.3 | 2 | 1.3 (0.15 to 4.56) | 0.8 | 7 | 1.0 (0.39 to 2.01) | −0.3 |
| Left-sided radiotherapy | 17 | 0.7 (0.40 to 1.10) | −11.8 | 6 | 1.2 (0.43 to 2.54) | 1.3 | 0 | 0.0 (0.00 to 1.97) | −2.9 | 4 | 0.5 (0.14 to 1.27) | −6.1 |
| Surgery only, right-sided | 82 | 0.7 (0.59 to 0.92) | −11.9 | 17 | 0.7 (0.43 to 1.19) | −2.4 | 2 | 0.2 (0.03 to 0.86) | −2.6 | 43 | 0.8 (0.57 to 1.07) | −4.4 |
| Surgery only, left-sided | 77 | 0.8 (0.63 to 1.00) | −9.4 | 18 | 0.9 (0.51 to 1.44) | −0.8 | 11 | 1.5 (0.76 to 2.71) | 1.8 | 39 | 0.9 (0.62 to 1.18) | −2.8 |
* Time at risk started 5 years after ductal carcinoma in situ diagnosis. Patients were censored at diagnosis of a second neoplasia treated with chemotherapy or radiotherapy above the diaphragm or date of emigration.
AER = absolute excess risk per 10000 patients per year; CI = confidence interval; DCIS = ductal carcinoma in situ; O = observed; SMR = standardized mortality ratio.
† I00-99 International Classification of Diseases, 10th Revision.
‡ I21-22 International Classification of Diseases, 10th Revision.
§ I20, 23-25 International Classification of Diseases, 10th Revision.
|| I30-33, 39-52 International Classification of Diseases, 10th Revision.