Table 5.
Competing risk regression analyses for different cardiovascular events in 5-year survivors of ductal carcinoma in situ*
| Risk factor | ICD-10 | No. of events | HR (95% CI) |
|---|---|---|---|
| Any cardiovascular event†,‡ | 613 | ||
| Surgery only | 475 | 1.00 (Referent) | |
| Right-sided radiotherapy | 65 | 1.08 (0.83 to 1.41) | |
| Left-sided radiotherapy | 73 | 1.01 (0.79 to 1.30) | |
| Left- vs right-sided radiotherapy | 138 | 0.94 (0.67 to 1.32) | |
| Cardiovascular death§ | I20-25, 30-52 | 125 | |
| Surgery only | 101 | 1.00 (Referent) | |
| Right-sided radiotherapy | 13 | 1.29 (0.72 to 2.31) | |
| Left-sided radiotherapy | 11 | 0.89 (0.48 t0 1.66) | |
| Left- vs right-sided radiotherapy | 24 | 0.70 (0.31 to 1.56) | |
| Hospital discharge diagnosis of cardiovascular disease‡ | I20-25, 30-52 | 542 | |
| Surgery only | 416 | 1.00 (Referent) | |
| Right-sided radiotherapy | 59 | 1.12 (0.85 to 1.48) | |
| Left-sided radiotherapy | 67 | 1.07 (0.82 to 1.38) | |
| Left- vs right-sided radiotherapy | 126 | 0.95 (0.67 to 1.36) | |
| Hospital discharge diagnosis of ischemic heart disease‡ | I20-25 | 253 | |
| Surgery only | 189 | 1.00 (Referent) | |
| Right-sided radiotherapy | 33 | 1.47 (1.01 to 2.13) | |
| Left-sided radiotherapy | 31 | 1.15 (0.78 to 1.68) | |
| Left- vs right-sided radiotherapy | 64 | 0.78 (0.48 to 1.27) | |
| Hospital discharge diagnosis of acute myocardial infarction‡ | I21 | 75 | |
| Surgery only | 62 | 1.00 (Referent) | |
| Right-sided radiotherapy | 8 | 1.13 (0.54 to 2.40) | |
| Left-sided radiotherapy | 5 | 0.59 (0.24 to 1.48) | |
| Left- vs right-sided radiotherapy | 13 | 0.52 (0.17 to 1.63) | |
| Hospital discharge diagnosis of angina pectoris‡ | I20 | 82 | |
| Surgery only | 55 | 1.00 (Referent) | |
| Right-sided radiotherapy | 16 | 2.53 (1.46 to 4.41) | |
| Left-sided radiotherapy | 11 | 1.43 (0.76 to 2.71) | |
| Left- vs right-sided radiotherapy | 27 | 0.57 (0.27 to 1.23) | |
| Hospital discharge diagnosis of other heart disease† | I30-52 | 340 | |
| Surgery only | 266 | 1.00 (Referent) | |
| Right-sided radiotherapy | 31 | 0.89 (0.61 to 1.31) | |
| Left-sided radiotherapy | 43 | 1.05 (0.76 to 1.46) | |
| Left- vs right-sided radiotherapy | 74 | 1.19 (0.75 to 1.91) | |
| Hospital discharge diagnosis of valvular dysfunction‡ | I34-38 | 37 | |
| Surgery only | 29 | 1.00 (Referent) | |
| Right-sided radiotherapy | 3 | 0.83 (0.25 to 2.71) | |
| Left-sided radiotherapy | 5 | 1.18 (0.47 to 2.94) | |
| Left- vs right-sided radiotherapy | 8 | 1.51 (0.36 to 6.28) | |
| Hospital discharge diagnosis of arrhythmia‡ | I47-49 | 205 | |
| Surgery only | 157 | 1.00 (Referent) | |
| Right-sided radiotherapy | 20 | 0.91 (0.57 to 1.48) | |
| Left-sided radiotherapy | 28 | 1.09 (0.73 to 1.64) | |
| Left- vs right-sided radiotherapy | 48 | 1.20 (0.67 to 2.15) | |
| Hospital discharge diagnosis of congestive heart failure‡ | I50 | 107 | |
| Surgery only | 87 | 1.00 (Referent) | |
| Right-sided radiotherapy | 10 | 1.04 (0.53 to 2.03) | |
| Left-sided radiotherapy | 10 | 0.87 (0.45 to 1.67) | |
| Left- vs right-sided radiotherapy | 20 | 0.83 (0.34 to 2.03) | |
| Cardiovascular surgical intervention§ | 164 | ||
| Surgery only | 125 | 1.00 (Referent) | |
| Right-sided radiotherapy | 20 | 1.44 (0.89 to 2.36) | |
| Left-sided radiotherapy | 19 | 1.12 (0.69 to 1.82) | |
| Left- vs right-sided radiotherapy | 39 | 0.78 (0.41 to 1.46) |
* With death treated as a competing risk. Adjusted for age at ductal carcinoma in situ (DCIS) diagnosis and year of DCIS diagnosis. Patients were censored at diagnosis of a second neoplasia treated with chemotherapy or radiotherapy above the diaphragm or date of emigration. Multiple cardiovascular events per person possible. CI = confidence interval; HR = hazard ratio; ICD-10 = International Classification of Diseases, 10th Revision.
† Cardiovascular death, hospital admission for cardiovascular disease, or surgical intervention for cardiovascular disease.
‡ Time at risk started at the first moment of becoming uniquely identifiable, with a minimum of 5 years after DCIS diagnosis.
§ Time at risk started 5 years after DCIS diagnosis.