Skip to main content
. 2014 Apr 22;2(3):e00042. doi: 10.1002/prp2.42

Figure 4.

Figure 4

Serum and urinary phosphate in 5/6 NX rats on high-phosphate diet. NX rats were dosed with vehicle (Veh: unprocessed polymer at 1 or 5%), VS-501 or sevelamer carbonate (concentrations at 0.2, 1 or 5%) in food for 4 weeks. Sham rats were on high-Pi diet with no addition of vehicle or binders. Blood and urine samples were collected at three different time points (predosing, at Week 2 after dosing, and at Week 4 after dosing) for Pi determination as described in Methods. Mean ± SE was calculated for each group (n = 7–12). (A) Serum Pi. (B) Urinary Pi in 24 h. One-way ANOVA and Dunnett test with 95% confidence intervals of difference was performed for statistical comparisons. #P < 0.05, ##P < 0.01, ###P < 0.001 versus predosing, same group. **P < 0.01, ***P < 0.001 versus Sham, same time point. Open bar: predosing. Solid bar: Week 2 after dosing. Pattern bar: Week 4 after dosing.