. 2014 Apr 22;2(3):e00042. doi: 10.1002/prp2.42

Table 2.

Serum BUN and creatinine in 5/6 nephrectomized uremic rats

	Serum BUN (mg/dL)			Serum creatinine (mg/dL)

Parameters	Predosing	Week 2	Week 4	Predosing	Week 2	Week 4
Sham	19.64 ± 0.88	18.65 ± 1.07	19.97 ± 0.78	0.41 ± 0.04	0.46 ± 0.03	0.38 ± 0.01
NX-1% vehicle	45.15 ± 2.40^a	46.20 ± 2.71^a	50.73 ± 5.79^a	0.79 ± 0.08^a	1.02 ± 0.04^a	0.96 ± 0.20^a
NX-5% vehicle	48.28 ± 3.64^a	46.14 ± 3.69^a	46.20 ± 3.92^a	0.93 ± 0.02^a	0.94 ± 0.05^a	0.87 ± 0.09^a
0.2% sevelamer	39.82 ± 3.09^a	42.09 ± 4.43^a	40.78 ± 6.00^a	0.77 ± 0.11^b	0.74 ± 0.04^b	0.85 ± 0.18^a
1% sevelamer	47.54 ± 2.06^a	41.87 ± 1.48^a	48.83 ± 2.86^a	0.80 ± 0.03^a	0.95 ± 0.02^a	0.91 ± 0.10^a
5% sevelamer	51.85 ± 2.92^a	47.55 ± 2.83^a	50.93 ± 4.61^a	0.93 ± 0.03^a	1.03 ± 0.04^a	1.02 ± 0.13^a
0.2% VS-501	42.70 ± 2.42^a	37.43 ± 1.37^a	38.54 ± 1.92^a	0.66 ± 0.03^c	0.70 ± 0.03^b	0.67 ± 0.03^c
1% VS-501	46.76 ± 1.81^a	41.52 ± 2.66^a	47.23 ± 2.46^a	0.75 ± 0.03^a	0.96 ± 0.02^a	0.76 ± 0.04^a
5% VS-501	52.85 ± 3.03^a	47.42 ± 2.99^a	53.04 ± 3.37^a	0.89 ± 0.03^a	1.04 ± 0.03^a	1.02 ± 0.08^a

Data are mean ± SE. One-way ANOVA and Dunnett test with 95% confidence intervals of difference was performed for statistical comparisons.

P < 0.001, ^bP < 0.01, ^cP < 0.05 versus sham, predosing. Predosing: Week 6 after surgery. Week 2: Week 8 after surgery with 2 weeks of dosing. Week 4: Week 10 after surgery with 4 weeks of dosing. Vehicle: unprocessed plant polymer. Sham rats were on high-Pi diet with no addition of vehicle or binders.