Table 3.

Serum and urinary calcium in 5/6 nephrectomized uremic rats

	Serum Ca (mg/dL)			Urinary Ca (mg in 24 h)
Parameters	Predosing	Week 2	Week 4	Predosing	Week 2	Week 4
Sham	10.95 ± 0.19	11.14 ± 0.25	10.89 ± 0.16	0.74 ± 0.09	0.79 ± 0.09	0.60 ± 0.06
NX-1% vehicle	10.91 ± 0.20	11.90 ± 0.32	11.07 ± 0.34	1.86 ± 0.28	1.48 ± 0.33	1.54 ± 0.27
NX-5% vehicle	11.18 ± 0.23	10.46 ± 0.14	9.86 ± 0.40	1.70 ± 0.23	1.91 ± 0.34	1.63 ± 0.29
0.2% sevelamer	11.37 ± 0.22	11.82 ± 0.41	11.98 ± 0.27	1.40 ± 0.15	2.22 ± 0.63	2.12 ± 0.65
1% sevelamer	11.00 ± 0.16	10.91 ± 0.18	11.28 ± 0.14	1.72 ± 0.28	2.10 ± 0.28	2.33 ± 0.24
5% sevelamer	11.39 ± 0.27	11.05 ± 0.29	10.52 ± 0.29	1.97 ± 0.23	3.38 ± 0.73a	3.32 ± 0.74a
0.2% VS-501	11.14 ± 0.16	11.48 ± 0.12	11.82 ± 0.22	0.95 ± 0.08	0.90 ± 0.06	1.14 ± 0.10
1% VS-501	11.06 ± 0.16	11.02 ± 0.36	11.30 ± 0.13	1.48 ± 0.14	1.12 ± 0.10	1.23 ± 0.11
5% VS-501	10.82 ± 0.18	11.25 ± 0.20	11.06 ± 0.18	1.90 ± 0.22	2.01 ± 0.33	2.02 ± 0.33

Data are mean ± SE. A t-test was used to assess differences between predosing and post dosing in the same group.

^aP < 0.05 versus predosing, same group. Predosing: Week 6 after surgery. Week 2: Week 8 after surgery with 2 weeks of dosing. Week 4: Week 10 after surgery with 4 weeks of dosing. Vehicle: unprocessed plant polymer. Sham rats were on high-Pi diet with no addition of vehicle or binders.