Table 5.

Absolute and percent change from baseline in PET/CT measurements of inflammation after 3 and 6 months (average of carotid arteries)

	Absolute values, mean (SE)		Least squares mean (SE) absolute or percent change from baseline		Absolute change from baseline relative to placebo (90% CI)	p value*
	Placebo	Dalcetrapib	Placebo	Dalcetrapib
Most diseased segment mean of maximumTBR†—absolutechange
Baseline	1·81 (0·08)	2·09 (0·09)	··	··	··	··
Month 3	1·86 (0·06)	1·97 (0·07)	−0·02 (0·06)	−0·11 (0·06)	−0·09 (−0·23 to 0·05)	0·31
Month 6	1·82 (0·05)	1·89 (0·06)	−0·04 (0·06)	−0·19 (0·06)	−0·15 (−0·29 to −0·01	0·08
Most diseased segment mean of maximumTBR†—percent change
Month 3	··	··	−0·5	−4·4	−4·0 (−10·4 to 2·9	0·33
Month 6	··	··	−1·1	−8·4	−7·3 (−13·5 to − 0·8)	0·07

SE=standard error. TBR=target to background ratio.

^*p-values (2-sided) are presented for the difference between groups.

^†n=24 for placebo and n=27 for dalcetrapib at baseline and month 6, and n=24 for placebo and n=26 for dalcetrapib at month 3.