Table 1. Transfusion requirements from day of last dose of study drug to CABG.
Variable | <5 Days | 6-7 Days | >7 Days | ||||||
---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
Prasugrel (n = 88) | Clopidogrel (n = 99) | P value* | Prasugrel (n = 34) | Clopidogrel (n = 41) | P value* | Prasugrel (n = 50) | Clopidogrel (n = 32) | P value* | |
Intraoperative | |||||||||
RBCs | 0.62 ± 1.14 | 0.84 ± 1.14 | .098 | 0.71 ± 1.69 | 0.59 ± 1.04 | .945 | 0.34 ± 0.67 | 0.79 ± 1.91 | .664 |
Platelets | 0.33 ± 1.20 | 0.22 ± 1.13 | .300 | 0 ± 0 | 0.05 ± 0.32 | .358 | 0.23 ± 1.46 | 0.29 ± 1.19 | .669 |
THCs | 0.77 ± 2.24 | 0.47 ± 1.56 | .267 | 0.09 ± 0.38 | 0.10 ± 0.45 | .887 | 0.30 ± 1.49 | 0.74 ± 2.25 | .485 |
TDE | 1.40 ± 2.64 | 1.30 ± 1.98 | .511 | 0.80 ± 1.89 | 0.69 ± 1.08 | .671 | 0.64 ± 1.65 | 1.53 ± 3.87 | .974 |
Postoperative | |||||||||
RBCs | 2.02 ± 3.34 | 1.27 ± 1.77 | .120 | 1.82 ± 2.44 | 0.92 ± 1.60 | .154 | 1.06 ± 1.69 | 0.84 ± 1.24 | .627 |
Platelets | 0.95 ± 2.84 | 0.25 ±1.14 | .018 | 0.18 ± 0.53 | 0.08 ± 0.48 | .127 | 0.15 ± 0.87 | 0.23 ± 1.09 | .653 |
THCs | 2.31 ± 5.81 | 0.72 ± 2.09 | .155 | 1.48 ± 3.13 | 0.64 ± 3.41 | .006 | 0.75 ± 1.80 | 0.68 ± 1.83 | .858 |
TDE | 4.34 ± 8.45 | 1.99 ± 3.28 | .267 | 3.30 ± 5.14 | 1.56 ± 4.71 | .107 | 1.81 ± 3.23 | 1.52 ± 2.71 | .504 |
Total | |||||||||
RBCs | 2.64 ± 3.91 | 2.11 ± 2.24 | .594 | 2.53 ± 2.96 | 1.51 ± 1.83 | .297 | 1.40 ± 1.94 | 1.63 ± 2.69 | .847 |
Platelets | 1.25 ± 3.25 | 0.47 ± 1.57 | .039 | 0.18 ± 0.53 | 0.13 ± 0.57 | .322 | 0.38 ± 1.67 | 0.52 ± 2.25 | .793 |
THCs | 3.08 ± 6.56 | 1.18 ± 2.51 | .194 | 1.58 ± 3.20 | 0.74 ± 3.42 | .036 | 1.04 ± 2.52 | 1.42 ± 3.88 | .888 |
TDE | 5.71 ± 9.45 | 3.29 ± 3.91 | .556 | 4.11 ± 5.64 | 2.26 ± 4.73 | .349 | 2.44 ± 3.80 | 3.05 ± 5.98 | .548 |
Data presented as mean ± standard deviation. Number of subjects included those from last day of drug to surgery. RBCs, Red blood cells (packed RBCs, whole blood); TDE, total donor exposure (RBCs, platelets, cryoprecipitate, plasma); THCs, total hemostatic components (platelets, cryoprecipitate, plasma).
P < .05 (Kruskal-Wallis test).