Table 1. Association of SNP rs1006737 bipolar risk allele (A) with decreased expression of CACNA1C in human cerebellum.
| Probe type | Probe ID | Frequency (A allele) | Effect | CHISQ | P-value | Corr_p |
|---|---|---|---|---|---|---|
| exon | 7953041 | 0.36 | -0.47 | 14.67 | 1.28E-04 | 0.026 |
| exon | 7953044 | 0.36 | -0.52 | 17.65 | 2.66E-05 | 0.006 |
| exon | 7953049 | 0.36 | -0.61 | 24.46 | 7.59E-07 | 0.001 |
| exon | 7953050 | 0.36 | -0.52 | 17.67 | 2.63E-05 | 0.004 |
| exon | 7953066 | 0.36 | -0.54 | 19.73 | 8.91E-06 | 0.004 |
| exon | 7953068 | 0.36 | -0.55 | 20.18 | 7.04E-06 | 0.002 |
| exon | 7953075 | 0.36 | -0.61 | 24.50 | 7.43E-07 | 0.001 |
| exon | 7953076 | 0.36 | -0.52 | 17.73 | 2.54E-05 | 0.004 |
| exon | 7953079 | 0.36 | -0.50 | 16.30 | 5.41E-05 | 0.014 |
| exon | 7953081 | 0.36 | -0.49 | 16.10 | 6.00E-05 | 0.026 |
| exon | 7953093 | 0.36 | -0.67 | 29.47 | 5.67E-08 | 0.001 |
| exon | 7953095 | 0.36 | -0.55 | 19.84 | 8.43E-06 | 0.004 |
| transcript | 7953040 | 0.36 | -0.60 | 23.73 | 1.11E-06 | 0.001 |
| transcript | 7953094 | 0.36 | -0.46 | 14.28 | 1.58E-04 | 0.048 |
Notes: EFFECT: Beta regression coefficient of expression on SNP after correcting for covariates; CHISQ: Test statistic; P-value for test statistic; Corr_p: regionwide-corrected p-value. Computation by MACHqtl (http://www.sph.umich.edu/csg/abecasis/MACH/download/).