Figure 1.
The response of Mdm2FM/−;CreER mice to daily Tamoxifen injection. A, H&E staining of paraffin-embedded sections of various tissues. B, Measurement of the blood urine nitrogen concentration (BUN) in blood samples. C, Measurement of the aspartate aminotransferase (AST) concentration in blood samples. Ctrl: the control Mdm2FM/− mice. FM/−;CreER: the Mdm2FM/−;CreER mice. Dashed circles indicate white pulp. Arrows indicate dilated tubules filled with protein cast. Scale bar, 100 μm. * p<0.05. The number of animals in each sample group is indicated on the top of each respective bar in B and C.