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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: Ann Appl Stat. 2012 Dec 1;6(4):1707–1729. doi: 10.1214/12-AOAS563

Fig. 2.

Fig. 2

Dose-response as a change-point model. (left) B-spline basis function of degree 1, corresponding to change points (interior knots) at log doses of 1.5 and 4.5. (Middle) Example dose-response curve. The basis function on the left corresponds to a spline function with 2 change points. Each random change point has a corresponding distribution, resulting in a smooth dose-response curve. (Right) Example of a marginal prior distribution on the change points corresponding to the dose-response curve on the left. This formulation favors (a priori) the choice of conservative values for the location of the first change point (solid line), and a relatively diffuse prior for our second change point (dotted line).