Fig. 3.

ROC for classification results. CDK2 was used as query to retrieve various protein families, such as class 1a — CDK2 entries itself, class 1b — serine–threonine protein kinases, and class 1 — protein kinases. Androgen receptor (AR) entries were used to retrieve just two classes: class 1a — androgen receptor themselves and class 1 — all nuclear receptors. Trypsin: class 1a — trypsin, class 1b — trypsin-like fold, class 1 — serine proteases. ROC AUC averaged according to true positive rate and the standard deviation boxplot was added for every curve.