Fig. 5.

Generative Topographic Mappings of various protein families: serine and aspartate proteases, serine/threonine and tyrosine protein kinases, phosphorylases and nuclear receptors extracted from sc-PDB. Composition of zones 1–4 is given in Supplementary material and discussed in Section 3.2. The following parameters have been used: map resolution 25 × 25, radial basis function network with grid 5 × 5 and width factor 1.0, regularization coefficient 0.1.