Figure 1.

Domain Organization of S. cerevisiae eIF3 and Experimental Approach

(A) Domain map of the six subunits of S. cerevisiae eIF3. Structured domains are shown as rectangles or spheres and are individually colored. Domains with known structural motifs are designated in the legend. Predicted unstructured regions are shown as thin gray lines. Known eIF3 interactions are indicated by arrows. Modules whose crystal structures are described in this paper are boxed, whereas previously described structures are indicated by narrow dashed lines.

(B) Schematic outline of the hybrid experimental approach, highlighting the techniques used in this study.