Fig. 5.

Responses of a type I cell to strong and weak synaptic stimuli. The active membrane is simulated without and with ion current fluctuations. A: Postsynaptic current as recorded in rat type I cells (Grant et al., 2010). B: Transmembrane voltage profiles at selected compartments for I₀ = 400 pA. C: Reduction of stimulus amplitude defers spike initiation. D: Including ion current fluctuation causes small jitter for strong stimulation, e.g. in central node C7. E: Decrease of stimulus intensity causes fewer spikes and a significantly increased jitter at C7. Simulated with standard cell I data of Fig. 1: d1 = 1 μm, d2 = 2 μm (peripheral and central axon diameters), soma diameter 20 μm.