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. 2014 Sep 2;9(9):e106242. doi: 10.1371/journal.pone.0106242

Figure 1. Mechanical stretch-induced mRNA expression of IL-1β, IL-6, IL-8, MCP-1, TNF-α, and iNOS in the primary culture of RCCSMCs.

Figure 1

Cells were stretched statically with 18% length elongation for 60 min and harvested 3 h after the start of stretch. The controls (time point 0) were treated identically, except that they were not subjected to stretch. The iNOS mRNA increased by 6.0 (±1.4), IL-6 mRNA increased by 2.5 (±0.5), and MCP-1 mRNA increased by 2.2 (±0.5) fold, respectively (N = 6 to 8, p<0.05 in all). However, gene expression of TNF, IL-1, and IL-8 was not significantly altered by the mechanical stretch.