Table 2.

Classification of IBD mouse models evaluated within this study

Organ	“First hit”	Induction	Example	Sampling1	Scheme
Colon	Outside	Induced by erosive chemicals	Oral DSS; single cycle	Distal colon, day 2-42	1 (Table 3, Figure 6)
			Oral DSS; repeated cycles	Distal colon, day 142
			Rectal TNBS; single dose	Distal colon, day 2-4
			Rectal oxazolone; single dose	Distal colon, day 2-4
		Mediated by luminal antigen	Rectal ovalbumin, transfer of OVA-specific CD8+ T cells	Colon3, week 6-8	2 (Table 4, Figure 7)
	Inside	Mediated by disturbed immune cell homeostasis	Transfer of naïve CD4+ T cells into syngeneic immunodeficient mice	Colon3, week 4-8	3 (Table 5, Figure 8)
		Mediated by genetically altered cytokine balance	Homozygous IL-10ko	Ascending and transverse colon, week 34	4 (Table 6, Figure 9)
			Homozygous IL-2ko	Colon3, week 6-15
Small intestine	Inside	Mediated by genetically altered cytokine balance	TNFΔARE/+	Terminal ileum, week 4-8	5 (Table 7, Figure 10)
	Outside	Mediated by luminal antigen	Oral infection with H. polygyrus	Duodenum, day 6	6 (Table 8, Figure 11)
			Oral infection with N. brasiliensis	Jejunum, day 7
			Oral infection with T. gondii	Ileum, day 7-8	(Table 9, Figure 12)

¹Most affected organ and time point of most severe inflammation; can vary according to the experimental setup;

²After DSS removal;

³Severity increases from proximal to distal colon;

⁴Development of chronic colitis and adenocarcinoma ≥3 months of age.