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The expression level of let-7a/b/c/d/e/f/g/i in OS cell (U2-OS and HOS) and osteoblast cell (HOB cell) was evaluated by qRT -PCR. The results revealed that expression of let-7i was significantly down-regulated in OS cells compare to that in osteoblast cells, suggesting that let-7a/b/c/d/e/f/g/i may play an essential role in OS. Let-7g was the most significantly changed let-7 miRNA. So it was chosen as the candidate miRNA to conduct functional investigation in OS.
