Table 1.
Foxp3 Tregs, DCs infiltration, and clinicopathologic parameters response to NACT
| NACT group | nNACT group | P value | |
|---|---|---|---|
| Number of patients | 56 | 46 | |
| Foxp3 Tregs (mean±SD) | 11.29±2.814 | 13.46±4.680 | 0.007 |
| Low, n (%) | 32 (57.1%) | 26 (56.5%) | |
| High, n (%) | 24 (42.9%) | 20 (43.5%) | |
| Dendritic cells (mean±SD) | 19.29±9.392 | 14.61±5.136 | 0.002 |
| High, n (%) | 28 (50.0%) | 20 (43.5%) | |
| Low, n (%) | 28 (50.0%) | 26 (56.5%) | |
| Status, n (%) | |||
| Event | 32 (57.1%) | 28 (60.9%) | |
| Censored | 24 (42.9%) | 18 (39.1%) | |
| Gender, n (%) | |||
| Male | 35 (62.5%) | 34 (73.9%) | 0.220 |
| Female | 21 (37.5%) | 12 (26.1%) | |
| Age, n (%) | |||
| <55 | 20 (35.7%) | 22 (47.8%) | 0.216 |
| ≥55 | 36 (64.3%) | 24 (52.2%) | |
| Lauren’s classification, n (%) | |||
| Intestinal | 15 (26.8%) | 10 (21.7%) | 0.555 |
| Diffuse | 41 (73.2%) | 36 (78.3%) | |
| Invasion depth, n (%) | |||
| T2 | 8 (14.3%) | 6 (13.0%) | 0.857 |
| T3/T4 | 48 (85.7%) | 40 (87.0%) | |
| TNM Stage, n (%) | |||
| I+II | 16 (28.6%) | 10 (21.7%) | 0.433 |
| III+IV | 40 (71.4%) | 36 (78.3%) | |
| Lymph node metastasis, n (%) | |||
| No | 27 (48.2%) | 16 (34.8%) | 0.172 |
| Yes | 29 (51.8%) | 30 (65.2%) |
T2, tumor invades the muscularis propria or subserosa; T3, tumor invasion extends to or beyond the serosa; T4, tumor invades adjacent structures. P and r values obtained using Spearman rank correlation.