Table 4.

Cox proportional hazards model analysis of prognostic factors

Variables	Multivariate analysis
	HR	95% CI	P value
Sema3a expression (High vs. low)	0.570	0.353-0.919	0.021*
TNM stage (III-IV vs. I-II)	0.453	0.288-0.713	0.001*
Depth of invasion (T3 + T4 vs. T1 + T2)	0.513	0.324-0.810	0.004*
Lymph node metastasis (positive vs. negative)	0.423	0.262-0.685	< 0.001*
Distant metastasis (M1 vs. M0)	0.350	0.224-0.545	< 0.001*
Gender (Male vs. Female)	0.824	0.530-1.282	0.390
Age (years) (≥ 50 vs. < 50)	1.358	0.876-2.107	0.171
Location (Cardia vs. Body/Antrum)	1.384	0.845-2.267	0.197
Vascular invasion (positive vs. negative)	0.439	0.273-0.704	0.001*
Differentiation (Well/moderate vs. poor)	0.449	0.284-0.709	0.001*

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor node metastasis;

^* P < 0.05 was considered significant.