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The abundance of podoplanin (PDPN)-positive cancer-associated fibroblasts per se has no prognostic effect (A). The prognostic effect of PDPN-positive fibroblasts is opposite in PDPN-low (B) and PDPN-high (C) tumors. Concordant PDPN expression (both high or both low) in fibroblasts and tumor cells is significantly associated with short survival (D).
