Table 1.

Association of the expression of MUC1, MUC2, MUC4, MUC5AC and MUC6 with clinicopathologic features of bladder cancer, occurrence of tumor relapse during the follow-up period and cancer specific death

χ 2 Pearson	Patients		MUC1			MUC2			MUC4			MUC5AC			MUC6
Characteristic			Positive			Positive			Positive			Positive			Positive
	No	%	No	%	P	No	%	P	No	%	P	No	%	P	No	%	P
Total	539	100	333	61.8		216	40.1		143	26.5		60	11.1		118	21.9
Gender
Female	116	21.5	81	24.3	0.044*	55	25.5	0.069	34	23.8	0.444	16	26.7	0.304	30	25.4	0.243
Male	423	78.5	252	75.7		161	74.5		109	76.2		44	73.3		88	74.6
Pathological stage
≤pT1	393	72.9	240	72.1	0.577	188	87.0	0.000*	96	67.1	0.070	48	80.0	0.190	100	84.7	0.001*
≥T2	146	27.1	93	27.9		28	13.0		47	32.9		12	20.0		18	15.3
Pathological grade
Low	288	53.4	164	49.2	0.013*	149	69.0	0.000*	62	43.4	0.005*	32	53.3	0.987	74	62.7	0.022*
High	251	46.6	169	50.8		67	31.0		81	56.8		28	46.7		44	37.3
Carcinoma in situ
Negative	496	92.0	305	91.6	0.639	206	95.4	0.019*	127	88.8	0.098	52	86.7	0.104	112	94.9	0.189
Positive	43	8.0	28	8.4		10	4.6		16	11.2		8	13.3		6	5.1
Divergent differentiation
Negative	470	87.2	277	83.2	0.000*	194	89.8	0.137	114	79.7	0.002*	47	78.3	0.029*	106	89.8	0.333
Positive	69	12.8	56	16.8		22	10.2		29	20.3		13	21.7		12	10.2
Tumor relapse
No	347	64.4	218	65.5	0.503	125	57.9	0.010*	90	62.9	0.675	34	56.7	0.186	69	59.5	0.130
Yes	192	35.6	115	34.5		91	42.1		53	37.1		26	43.3		49	41.5
Cancer specific death
No	357	66.2	215	64.6	0.297	164	75.9	0.000*	84	58.7	0.027*	45	75.0	0.128	91	77.1	0.005*
Yes	182	33.8	118	35.4		52	24.1		59	41.3		15	25.0		27	22.9

^*P≤0.05, the result is statistically significant.