Table 3.

Genotypes of hsa-miR-1 binding site rs9548934 C>T polymorphisms and the HR of the cardiovascular events on the patients with CAD

Genotypes	Cases N	Events N	Log-rank P	Adjusted HRe (95% CI)	P
hsa-miR-1 binding site in COG6 rs9548934 C→Ta
CC	288	116	< 0.001	1.00
CT	242	103		0.78 (0.58-1.04)	0.085
TT	134	33		0.24 (0.16-0.36)	< 0.001
CT/TT	376	136	< 0.001	0.51 (0.39-0.68)	< 0.001
CRP levels cut off by the median of the follow-up patients (mg/L)b
< 3.80	321	65	< 0.001	1.00
≥ 3.80	322	181		3.44 (2.55-4.64)	< 0.001
Delta Ct of plasma miRNA-1 cut off by the median of the follow-up patientsc
< 4.63	18	7	0.582	1.00	0.826
≥ 4.63	18	5		0.82 (0.14-4.77)
Numbers of pathological changes in coronary arteriesd,f
1	291	85	< 0.001	1.00
2	147	57		1.24 (0.87-1.75)	0.235
3	177	91		1.84 (1.36-2.50)	< 0.001

^a664 CAD patients were followed up with the detected genotype of rs9548934 and 252 patients obtained the CAD events.

^b643 CAD patients were followed up with the detected CRP levels and 246 patients obtained the CAD events.

^c36 CAD Patients were followed up with the detected plasma miRNA-1 levels and 12 patients obtained the CAD events.

^d615 CAD Patients were followed up with the detected plasma miRNA-1 levels and 233 patients obtained the CAD events.

^eAdjusted for age, sex, smoking status, TD, hypertension and numbers of pathological changes in coronary arteries.

^fAdjusted for age, sex, smoking status, TD, hypertension.