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. 2014 Sep 2;9(9):e105110. doi: 10.1371/journal.pone.0105110

Table 1. Age restrictions and indications for selected respiratory drug classes.

Compound class Compound ATC-code* Age restriction Approved indication(s)
Inhaled SABA Salbutamol R03AC02 None Asthma, chronic obstructive bronchitis, pulmonary emphysema with reversible obstruction, prophylaxis of allergic asthma and exercise-induced asthma
Fenoterol R03AC04 ≥4 years Asthma, chronic obstructive bronchitis, pulmonary emphysema with reversible obstruction, prophylaxis of allergic asthma and exercise-induced asthma
Terbutaline R03AC03 ≥5 years Asthma, chronic obstructive bronchitis, pulmonary emphysema with reversible obstruction
Inhaled SABA combination Ipratropium/Fenoterol (fixed combination) R03AK03 None Asthma, COPD
Reproterol/CGA (fixed combination) R03AK05 None Asthma
Inhaled LABA Salmeterol R03AC12 ≥4 years Asthma, COPD
Formoterol R03AC13 ≥6 years Asthma, COPD
Inhaled LABA/ICS Salmeterol/Fluticasone (fixed combination) R03AK06 ≥4 years Asthma, COPD
Formoterol/Beclomethasone (fixed combination) R03AK27 ≥6 years Asthma
Formoterol/Budesonide (fixed combination) R03AK28 ≥6 years Asthma, COPD
Inhaled SAMA Ipratropium R03BB01 None Asthma, COPD
Inhaled LAMA Tiotropium R03BB04 ≥18 years COPD
ICS Budesonide R03BA02 None Respiratory diseases (inclusive asthma and COPD) requiring ICS
Beclomethasone R03BA01 None Respiratory diseases (inclusive asthma and COPD) requiring ICS
Fluticasone R03BA05 ≥4 years Asthma, COPD
Ciclesonide R03BA08 ≥12 years Asthma
Oral B2A Salbutamol R03CC02 None Obstructive respiratory diseases, asthma, COPD, pulmonary emphysema
Terbutaline R03CC03 None Obstructive respiratory diseases, asthma, COPD, pulmonary emphysema
Tulobuterol R03CC11 ≥1year Obstructive respiratory diseases, asthma, COPD, pulmonary emphysema
Clenbuterol R03CC13 None Asthma, asthmatic bronchitis, chronic bronchitis, pulmonary emphysema
Oral B2A combinations Clenbuterol/Ambroxol R03CC63 None Acute and chronic bronchitis, pulmonary emphysema, asthma
Others Theophylline R03DA04 ≥1year Asthma, COPD
Montelukast R03DC03 ≥1 year Asthma, prophylaxis of exercise-induced asthma
Cromoglicic acid R03BC01 ≥2 years Asthma

SABA: Short-acting beta-2-agonist, CGA: Cromoglicic acid, LABA: Long-acting beta-2-agonist, ICS: Inhaled corticosteroid, SAMA: Short-acting muscarinic antagonist, LAMA: Long-acting muscarinic antagonist, B2A: Beta-2-agonist. (*German version available at http://www.dimdi.de/static/de/amg/atcddd/index.htm).